The cervical sympathetic trunk-submandibular gland axis modulates neutrophil and mast cell functions

Ronald Mathison; Elyse Bissonnette; Lisa Carter; Joseph S. Davison; Dean Befus

doi:10.1159/000236301

The cervical sympathetic trunk-submandibular gland axis modulates neutrophil and mast cell functions

Ronald Mathison, Elyse Bissonnette, Lisa Carter, Joseph S. Davison, Dean Befus

Centre for Science

University of Calgary

Research output: Contribution to journal › Journal Article › peer-review

3 Citations (Scopus)

Abstract

Decentralization or removal (ganglioncctomy) of the superior cervical ganglia (SCG) reduces the responses of circulating neutrophils to chemotactic stimuli and attenuates the pulmonary neutrophilia that develops 8 h after antigen challenge of Nippostrongylus brasiliensis-sensitized rats. The denervation- induced modification in neutrophil function is reserved by removal of the submandibular glands. In contrast, the reduced TNF-α release from mast cells seen in both decentralized and sialadenectomized rats was abolished if both operations were performed in the same animal. Multiple mechanisms appear to exist by which the cervical sympathetic trunk-submandibular axis regulates immunological function.

Original language	English
Pages (from-to)	419-421
Number of pages	3
Journal	International Archives of Allergy and Immunology
Volume	99
Issue number	2-4
DOIs	https://doi.org/10.1159/000236301
Publication status	Published - 1992

Keywords

Chemotaxis
Mast cells
Neutrophils
Pulmonary inflammation
Salivary glands
Superior cervical ganglia
TNF-α

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10.1159/000236301

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title = "The cervical sympathetic trunk-submandibular gland axis modulates neutrophil and mast cell functions",

abstract = "Decentralization or removal (ganglioncctomy) of the superior cervical ganglia (SCG) reduces the responses of circulating neutrophils to chemotactic stimuli and attenuates the pulmonary neutrophilia that develops 8 h after antigen challenge of Nippostrongylus brasiliensis-sensitized rats. The denervation- induced modification in neutrophil function is reserved by removal of the submandibular glands. In contrast, the reduced TNF-α release from mast cells seen in both decentralized and sialadenectomized rats was abolished if both operations were performed in the same animal. Multiple mechanisms appear to exist by which the cervical sympathetic trunk-submandibular axis regulates immunological function.",

keywords = "Chemotaxis, Mast cells, Neutrophils, Pulmonary inflammation, Salivary glands, Superior cervical ganglia, TNF-α",

author = "Ronald Mathison and Elyse Bissonnette and Lisa Carter and Davison, {Joseph S.} and Dean Befus",

year = "1992",

doi = "10.1159/000236301",

language = "English",

volume = "99",

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T1 - The cervical sympathetic trunk-submandibular gland axis modulates neutrophil and mast cell functions

AU - Mathison, Ronald

AU - Bissonnette, Elyse

AU - Carter, Lisa

AU - Davison, Joseph S.

AU - Befus, Dean

PY - 1992

Y1 - 1992

N2 - Decentralization or removal (ganglioncctomy) of the superior cervical ganglia (SCG) reduces the responses of circulating neutrophils to chemotactic stimuli and attenuates the pulmonary neutrophilia that develops 8 h after antigen challenge of Nippostrongylus brasiliensis-sensitized rats. The denervation- induced modification in neutrophil function is reserved by removal of the submandibular glands. In contrast, the reduced TNF-α release from mast cells seen in both decentralized and sialadenectomized rats was abolished if both operations were performed in the same animal. Multiple mechanisms appear to exist by which the cervical sympathetic trunk-submandibular axis regulates immunological function.

AB - Decentralization or removal (ganglioncctomy) of the superior cervical ganglia (SCG) reduces the responses of circulating neutrophils to chemotactic stimuli and attenuates the pulmonary neutrophilia that develops 8 h after antigen challenge of Nippostrongylus brasiliensis-sensitized rats. The denervation- induced modification in neutrophil function is reserved by removal of the submandibular glands. In contrast, the reduced TNF-α release from mast cells seen in both decentralized and sialadenectomized rats was abolished if both operations were performed in the same animal. Multiple mechanisms appear to exist by which the cervical sympathetic trunk-submandibular axis regulates immunological function.

KW - Chemotaxis

KW - Mast cells

KW - Neutrophils

KW - Pulmonary inflammation

KW - Salivary glands

KW - Superior cervical ganglia

KW - TNF-α

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U2 - 10.1159/000236301

DO - 10.1159/000236301

M3 - Journal Article

AN - SCOPUS:0027099923

SN - 1018-2438

VL - 99

SP - 419

EP - 421

JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

IS - 2-4

ER -

The cervical sympathetic trunk-submandibular gland axis modulates neutrophil and mast cell functions

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Keywords

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