Temporal analysis of the anti-inflammatory effects of decentralization of the rat superior cervical ganglia

R. Mathison, L. Carter, C. Mowat, E. Bissonnette, J. S. Davison, A. D. Befus

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20 Citations (Scopus)


Bilateral decentralization of the superior cervical ganglia (SCG) reduced the pulmonary inflammation that develops 4-8 h after induction of anaphylaxis in Nippostrongylus brasiliensis-sensitized rats. Histamine levels in peritoneal lavage fluid and rat mast cell protease type II in serum were increased to comparable levels in sham-operated and decentralized rats. In vitro stimulation of alveolar macrophages (ALM) with lipopolysaccharide (LPS) provoked tumor necrosis factor-α (TNF-α) release that was two to three times greater with unchallenged decentralized rats than with sham-operated rats. However, after allergen challenge LPS-stimulated TNF-α release from ALM of sham-operated rats increased threefold and lasted at least 24 h, whereas with decentralized rats release of this cytokine actually decreased at 4 and 8 h. The increase in the phagocytosis and respiratory burst of circulating neutrophils seen at 4 and 8 h after allergen challenge in sham- operated rats was reduced significantly by decentralization. These results suggest that the attenuation of anaphylaxis-induced pulmonary inflammation that occurs with decentralization of the SCG is primarily associated with downregulation of neutrophil and macrophage functions.

Original languageEnglish
Pages (from-to)R1537-R1543
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number5 35-5
Publication statusPublished - 1994


  • anaphylaxis
  • bronchoalveolar lavage
  • histamine
  • macrophages
  • neutrophils
  • sympathetic nervous system
  • tumor necrosis factor-α


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