TY - JOUR
T1 - Source of human milk (mother or donor) is more important than fortifier type (human or bovine) in shaping the preterm infant microbiome
AU - Kumbhare, Shreyas V.
AU - Jones, William Diehl
AU - Fast, Sharla
AU - Bonner, Christine
AU - Jong, Geert ‘t
AU - Van Domselaar, Gary
AU - Graham, Morag
AU - Narvey, Michael
AU - Azad, Meghan B.
N1 - Publisher Copyright:
© 2022
PY - 2022/9/20
Y1 - 2022/9/20
N2 - Milk fortifiers help meet the nutritional needs of preterm infants receiving their mother's own milk (MOM) or donor human milk. We conducted a randomized clinical trial (NCT03214822) in 30 very low birth weight premature neonates comparing bovine-derived human milk fortifier (BHMF) versus human-derived fortifier (H2MF). We found that fortifier type does not affect the overall microbiome, although H2MF infants were less often colonized by an unclassified member of Clostridiales Family XI. Secondary analyses show that MOM intake is strongly associated with weight gain and microbiota composition, including Bifidobacterium, Veillonella, and Propionibacterium enrichment. Finally, we show that while oxidative stress (urinary F2-isoprostanes) is not affected by fortifier type or MOM intake, fecal calprotectin is higher in H2MF infants and lower in those consuming more MOM. Overall, the source of human milk (mother versus donor) appears more important than the type of milk fortifier (human versus bovine) in shaping preterm infant gut microbiota.
AB - Milk fortifiers help meet the nutritional needs of preterm infants receiving their mother's own milk (MOM) or donor human milk. We conducted a randomized clinical trial (NCT03214822) in 30 very low birth weight premature neonates comparing bovine-derived human milk fortifier (BHMF) versus human-derived fortifier (H2MF). We found that fortifier type does not affect the overall microbiome, although H2MF infants were less often colonized by an unclassified member of Clostridiales Family XI. Secondary analyses show that MOM intake is strongly associated with weight gain and microbiota composition, including Bifidobacterium, Veillonella, and Propionibacterium enrichment. Finally, we show that while oxidative stress (urinary F2-isoprostanes) is not affected by fortifier type or MOM intake, fecal calprotectin is higher in H2MF infants and lower in those consuming more MOM. Overall, the source of human milk (mother versus donor) appears more important than the type of milk fortifier (human versus bovine) in shaping preterm infant gut microbiota.
KW - calprotectin
KW - gut inflammation
KW - gut microbiome
KW - human donor milk
KW - human milk fortifiers
KW - mother's own milk
KW - oxidative stress
KW - very low birth weight infants
UR - http://www.scopus.com/inward/record.url?scp=85138142454&partnerID=8YFLogxK
U2 - 10.1016/j.xcrm.2022.100712
DO - 10.1016/j.xcrm.2022.100712
M3 - Journal Article
C2 - 36029771
AN - SCOPUS:85138142454
VL - 3
JO - Cell Reports Medicine
JF - Cell Reports Medicine
IS - 9
M1 - 100712
ER -