TY - JOUR
T1 - Selenium and cabbage and colon carcinogenesis in mice
AU - Temple, N. J.
AU - Basu, T. K.
N1 - Funding Information:
I Received January 3D, 1987; accepted July 2, 1987. 2 Department of Foods and Nutrition, University of Alberta, Edmonton, Canada T6G 2M8. 3 Address reprint requests to Dr. Basu. 4The authors thank Mr. Arin Bhattacharjee (Department of Foods and Nutrition, University of Alberta) for technical assistance. We thank Mrs. Mabel Baaske and Mrs. Sandra Casovan (Department of Pathology, University Hospital, Edmonton) for histologic work and Dr. Lawrence Jewell (Department of Pathology, University Hospital, Edmonton) for advice on the interpretation of colon tumors. We also thank The Alberta Heritage Foundation for Medical Research for financial support.
PY - 1987
Y1 - 1987
N2 - The influence of dietary selenium and cabbage on the formation of colon tumors in female Swiss mice treated with 1,2-dimethylhydrazine [(DMH) CAS: 540-73-8] was reported. Mice received a control diet (laboratory chow), the control diet plus selenium in the drinking water (1 mg/liter), or the control diet with added cabbage (12.8 g/100 g diet). They also received 8 weekly sc injections of DMH. The experiment was divided into two time periods: a) from 5 weeks before the first injection until 3 days after the last one (initiation period), and b) the subsequent 19.5 weeks until sacrifice of the mice (promotion period). Selenium had a strong protective effect when given during the initiation period; adenomas were reduced to a much greater extent than adenocarcinomas. The only effect of selenium supplementation in the promotion period was a small decrease in adenomas. Cabbage apparently had two opposing actions. It increased tumor incidence, particularly adenocarcinomas, if given in the initiation period, but it reduced adenoma formation considerably when given in the promotion period.
AB - The influence of dietary selenium and cabbage on the formation of colon tumors in female Swiss mice treated with 1,2-dimethylhydrazine [(DMH) CAS: 540-73-8] was reported. Mice received a control diet (laboratory chow), the control diet plus selenium in the drinking water (1 mg/liter), or the control diet with added cabbage (12.8 g/100 g diet). They also received 8 weekly sc injections of DMH. The experiment was divided into two time periods: a) from 5 weeks before the first injection until 3 days after the last one (initiation period), and b) the subsequent 19.5 weeks until sacrifice of the mice (promotion period). Selenium had a strong protective effect when given during the initiation period; adenomas were reduced to a much greater extent than adenocarcinomas. The only effect of selenium supplementation in the promotion period was a small decrease in adenomas. Cabbage apparently had two opposing actions. It increased tumor incidence, particularly adenocarcinomas, if given in the initiation period, but it reduced adenoma formation considerably when given in the promotion period.
UR - http://www.scopus.com/inward/record.url?scp=0023637902&partnerID=8YFLogxK
M3 - Journal Article
C2 - 3479639
AN - SCOPUS:0023637902
SN - 0027-8874
VL - 79
SP - 1131
EP - 1134
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 5
ER -
