TY - JOUR
T1 - Second trimester serum cortisol and preterm birth
T2 - an analysis by timing and subtype
AU - Bandoli, Gretchen
AU - Jelliffe-Pawlowski, Laura L.
AU - Feuer, Sky K.
AU - Liang, Liang
AU - Oltman, Scott P.
AU - Paynter, Randi
AU - Ross, Kharah M.
AU - Schetter, Christine Dunkel
AU - Ryckman, Kelli K.
AU - Chambers, Christina D.
N1 - Funding Information:
Acknowledgements This work was supported by NIH/NHLBI grants (RC2 HL101748, RO1 HD-57192, and R01 HD-52953), the Bill and Melinda Gates Millennium grants (OPP52256 and RSDP 5K12 HD-00849-23), March of Dimes grants (6-FY11-261 and FY10-180), and the California Preterm Birth Initiative at the UCSF Benioff Children’s Hospital funded by Marc and Lynne Benioff. Data from the California Prenatal Screening Program were obtained through the California Biobank Program (Screening Information System request no. 476). Data were obtained with an agreement that the California Department of Public Health is not responsible for the results or conclusions drawn by the authors of this publication.
Publisher Copyright:
© 2018, Nature America, Inc., part of Springer Nature.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Objective: We hypothesized second trimester serum cortisol would be higher in spontaneous preterm births compared to provider-initiated (previously termed ‘medically indicated’) preterm births. Study design: We used a nested case-control design with a sample of 993 women with live births. Cortisol was measured from serum samples collected as part of routine prenatal screening. We tested whether mean-adjusted cortisol fold-change differed by gestational age at delivery or preterm birth subtype using multivariable linear regression. Result: An inverse association between cortisol and gestational age category (trend p = 0.09) was observed. Among deliveries prior to 37 weeks, the mean-adjusted cortisol fold-change values were highest for preterm premature rupture of the membranes (1.10), followed by premature labor (1.03) and provider-initiated preterm birth (1.01), although they did not differ statistically. Conclusion: Cortisol continues to be of interest as a marker of future preterm birth. Augmentation with additional biomarkers should be explored.
AB - Objective: We hypothesized second trimester serum cortisol would be higher in spontaneous preterm births compared to provider-initiated (previously termed ‘medically indicated’) preterm births. Study design: We used a nested case-control design with a sample of 993 women with live births. Cortisol was measured from serum samples collected as part of routine prenatal screening. We tested whether mean-adjusted cortisol fold-change differed by gestational age at delivery or preterm birth subtype using multivariable linear regression. Result: An inverse association between cortisol and gestational age category (trend p = 0.09) was observed. Among deliveries prior to 37 weeks, the mean-adjusted cortisol fold-change values were highest for preterm premature rupture of the membranes (1.10), followed by premature labor (1.03) and provider-initiated preterm birth (1.01), although they did not differ statistically. Conclusion: Cortisol continues to be of interest as a marker of future preterm birth. Augmentation with additional biomarkers should be explored.
UR - http://www.scopus.com/inward/record.url?scp=85047275347&partnerID=8YFLogxK
U2 - 10.1038/s41372-018-0128-5
DO - 10.1038/s41372-018-0128-5
M3 - Journal Article
C2 - 29795321
AN - SCOPUS:85047275347
SN - 0743-8346
VL - 38
SP - 973
EP - 981
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 8
ER -