TY - JOUR
T1 - Reference values for young normal Sprague-Dawley rats
T2 - Weight gain, hematology and clinical chemistry
AU - Lillie, Len E.
AU - Temple, Norman J.
AU - Florence, L. Zack
PY - 1996/8
Y1 - 1996/8
N2 - 1 Arterial blood from 63 male (315 - 500 g) and 60 female (210 - 290 g) healthy Sprague-Dawley rats was ana lyzed for 16 hematological and 22 clinical chemistry parameters. 2 Nine of these parameters were associated with growth and developmental changes in males between 38 - 78 days and females 49 - 89 days of age. 3 Weight gain in both sexes followed patterns consistent with other studies using this strain, but interexperi mental variation was as much as ± 22%. 4 Rectal temperatures of females averaged 37.28°C, being statistically greater (P < 0.05) than the average male at 36.99°C. 5 The data provide reference values for use in toxicolo gical and other investigations.
AB - 1 Arterial blood from 63 male (315 - 500 g) and 60 female (210 - 290 g) healthy Sprague-Dawley rats was ana lyzed for 16 hematological and 22 clinical chemistry parameters. 2 Nine of these parameters were associated with growth and developmental changes in males between 38 - 78 days and females 49 - 89 days of age. 3 Weight gain in both sexes followed patterns consistent with other studies using this strain, but interexperi mental variation was as much as ± 22%. 4 Rectal temperatures of females averaged 37.28°C, being statistically greater (P < 0.05) than the average male at 36.99°C. 5 The data provide reference values for use in toxicolo gical and other investigations.
KW - blood chemical analysis
KW - body temperature
KW - body weight
KW - electro lytes
UR - http://www.scopus.com/inward/record.url?scp=0029830702&partnerID=8YFLogxK
U2 - 10.1177/096032719601500802
DO - 10.1177/096032719601500802
M3 - Journal Article
C2 - 8863053
AN - SCOPUS:0029830702
SN - 0960-3271
VL - 15
SP - 612
EP - 616
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
IS - 8
ER -