Reference values for young normal Sprague-Dawley rats: Weight gain, hematology and clinical chemistry

Len E. Lillie, Norman J. Temple, L. Zack Florence

Research output: Contribution to journalJournal Articlepeer-review

98 Citations (Scopus)

Abstract

1 Arterial blood from 63 male (315 - 500 g) and 60 female (210 - 290 g) healthy Sprague-Dawley rats was ana lyzed for 16 hematological and 22 clinical chemistry parameters. 2 Nine of these parameters were associated with growth and developmental changes in males between 38 - 78 days and females 49 - 89 days of age. 3 Weight gain in both sexes followed patterns consistent with other studies using this strain, but interexperi mental variation was as much as ± 22%. 4 Rectal temperatures of females averaged 37.28°C, being statistically greater (P < 0.05) than the average male at 36.99°C. 5 The data provide reference values for use in toxicolo gical and other investigations.

Original languageEnglish
Pages (from-to)612-616
Number of pages5
JournalHuman & Experimental Toxicology
Volume15
Issue number8
DOIs
Publication statusPublished - Aug. 1996

Keywords

  • blood chemical analysis
  • body temperature
  • body weight
  • electro lytes

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