TY - JOUR
T1 - Physiology and endocrinology of zinc accumulation during the female squirrelfish reproductive cycle
AU - Thompson, E. D.
AU - Mayer, G. D.
AU - Balesaria, S.
AU - Glover, C. N.
AU - Walsh, P. J.
AU - Hogstrand, C.
N1 - Funding Information:
The authors wish to thank Dr Ram Abuknesha at King's College, London, for supplying antibodies to VTG, Dr Henry Feddern at Tavernier, Florida for supplying squirrelfish, and Mr Tom Capo, RSMAS, University of Miami, for assistance in the care of the fish. This research was supported by Grant IBN-9631411 from the National Science Foundation to C. Hogstrand and an NIEHS Center grant (P30 ES05705) to the University of Miami.
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Females of the squirrelfish family (Holocentridae) accumulate higher levels of hepatic zinc than any other studied animal. This accumulation is accompanied by high expression of the zinc-binding protein, metallothionein (MT), and is strongly correlated to the onset of sexual maturity. In an attempt to further characterize the timeframe of this accumulation, and to possibly discern any potential mediators, we examined the physiology and endocrinology of the yearly reproductive cycle of mature female squirrelfish. There are two separate reproductive events during the year in December-January and again in March-April, as evidenced by peaks in ovarian growth, VTG production, steroid levels, zinc accumulation and redistribution. Increased hepatic zinc seems to be preceded by a necessary increase in MT, but this was not clearly correlated to plasma 17β-estradiol, testosterone, or progesterone levels. The plasma zinc protein vitellogenin (VTG) is one, but probably not the predominant, vehicle for the transport of hepatic zinc to the ovary.
AB - Females of the squirrelfish family (Holocentridae) accumulate higher levels of hepatic zinc than any other studied animal. This accumulation is accompanied by high expression of the zinc-binding protein, metallothionein (MT), and is strongly correlated to the onset of sexual maturity. In an attempt to further characterize the timeframe of this accumulation, and to possibly discern any potential mediators, we examined the physiology and endocrinology of the yearly reproductive cycle of mature female squirrelfish. There are two separate reproductive events during the year in December-January and again in March-April, as evidenced by peaks in ovarian growth, VTG production, steroid levels, zinc accumulation and redistribution. Increased hepatic zinc seems to be preceded by a necessary increase in MT, but this was not clearly correlated to plasma 17β-estradiol, testosterone, or progesterone levels. The plasma zinc protein vitellogenin (VTG) is one, but probably not the predominant, vehicle for the transport of hepatic zinc to the ovary.
KW - 17β-Estradiol (E)
KW - Fish
KW - Liver
KW - Metallothionein (MT)
KW - Ovary
KW - Reproduction
KW - Sex steroids
KW - Squirrelfish
KW - Vitellogenin (VTG)
KW - Zinc
UR - http://www.scopus.com/inward/record.url?scp=0038278659&partnerID=8YFLogxK
U2 - 10.1016/S1095-6433(03)00015-1
DO - 10.1016/S1095-6433(03)00015-1
M3 - Journal Article
C2 - 12814790
AN - SCOPUS:0038278659
SN - 1095-6433
VL - 134
SP - 819
EP - 828
JO - Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology
JF - Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology
IS - 4
ER -