TY - JOUR
T1 - Partner social support during pregnancy and the postpartum period and inflammation in 3-month-old infants
AU - Ross, Kharah M.
AU - Thomas, Jenna C.
AU - Letourneau, Nicole L.
AU - Campbell, Tavis S.
AU - Giesbrecht, Gerald F.
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/5
Y1 - 2019/5
N2 - Prenatal social stress “programs” offspring immune activity in animal models, but how the prenatal social environment affects human offspring inflammation is not known. Here, we test associations between prenatal partner support quality, i.e. positive/helpful support, negative/upsetting support, and their interaction, and infant inflammatory markers. A sample of 113 women from the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort were followed from early pregnancy to 3-months postpartum. Partner support quality was measured during pregnancy and the postpartum period. Three-month-old infant blood samples were assayed for inflammatory markers, i.e., adaptive immune markers IFNγ IL12p70 and IL10. The prenatal positive-by-negative partner support interaction predicted infant IFNγ IL12p70, and IL10, p's<.035, independent of covariates and postpartum partner support. When negative partner support was high, high positive support predicted higher infant IFNγ IL12p70, and IL10. As such, partner support during pregnancy that is both highly negative/upsetting and also highly positive/helpful predicted adaptive immunity markers in infants at 3 months of age.
AB - Prenatal social stress “programs” offspring immune activity in animal models, but how the prenatal social environment affects human offspring inflammation is not known. Here, we test associations between prenatal partner support quality, i.e. positive/helpful support, negative/upsetting support, and their interaction, and infant inflammatory markers. A sample of 113 women from the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort were followed from early pregnancy to 3-months postpartum. Partner support quality was measured during pregnancy and the postpartum period. Three-month-old infant blood samples were assayed for inflammatory markers, i.e., adaptive immune markers IFNγ IL12p70 and IL10. The prenatal positive-by-negative partner support interaction predicted infant IFNγ IL12p70, and IL10, p's<.035, independent of covariates and postpartum partner support. When negative partner support was high, high positive support predicted higher infant IFNγ IL12p70, and IL10. As such, partner support during pregnancy that is both highly negative/upsetting and also highly positive/helpful predicted adaptive immunity markers in infants at 3 months of age.
KW - Infant
KW - Inflammation
KW - Postpartum period
KW - Pregnancy
KW - Social support
UR - http://www.scopus.com/inward/record.url?scp=85063223267&partnerID=8YFLogxK
U2 - 10.1016/j.biopsycho.2019.03.005
DO - 10.1016/j.biopsycho.2019.03.005
M3 - Journal Article
C2 - 30885739
AN - SCOPUS:85063223267
SN - 0301-0511
VL - 144
SP - 11
EP - 19
JO - Biological Psychology
JF - Biological Psychology
ER -