Maternal anxiety, depression and stress affects offspring gut microbiome diversity and bifidobacterial abundances

Jeffrey D. Galley, Lauren Mashburn-Warren, Lexie C. Blalock, Christian L. Lauber, Judith E. Carroll, Kharah M. Ross, Calvin Hobel, Mary Coussons-Read, Christine Dunkel Schetter, Tamar L. Gur

Research output: Contribution to journalJournal Articlepeer-review

42 Citations (Scopus)

Abstract

Uncovering mechanisms underlying fetal programming during pregnancy is of critical importance. Atypical neurodevelopment during the pre- and immediate postnatal period has been associated with long-term adverse health outcomes, including mood disorders and aberrant cognitive ability in offspring. Maternal factors that have been implicated in anomalous offspring development include maternal inflammation and tress, anxiety, and depression. One potential mechanism through which these factors perturb normal offspring postnatal development is through microbiome disruption. The mother is a primary source of early postnatal microbiome seeding for the offspring, and the transference of a healthy microbiome is key in normal neurodevelopment. Since psychological stress, mood disorders, and inflammation have all been implicated in altering maternal microbiome community structure, passing on aberrant microbial communities to the offspring that may then affect developmental outcomes. Therefore, we examined how maternal stress, anxiety and depression assessed with standardized instruments, and maternal inflammatory cytokine levels in the pre- and postnatal period are associated with the offspring microbiome within the first 13 months of life, utilizing full length 16S sequencing on infant stool samples, that allowed for species-level resolution. Results revealed that infants of mothers who reported higher anxiety and perceived stress had reduced alpha diversity. Additionally, the relative taxonomic quantitative abundances of Bifidobacterium dentium and other species that have been associated with either modulation of the gut-brain axis, or other beneficial health outcomes, were reduced in the offspring of mothers with higher anxiety, perceived stress, and depression. We also found associations between bifidobacteria and prenatal maternal pro-inflammatory cytokines IL-6, IL-8, and IL-10. In summary, specific microbial taxa involved in maintaining proper brain and immune function are lower in offspring born to mothers with anxiety, depression, or stress, providing strong evidence for a mechanism by which maternal factors may affect offspring health through microbiota dysregulation.

Original languageEnglish
Pages (from-to)253-264
Number of pages12
JournalBrain, Behavior, and Immunity
Volume107
DOIs
Publication statusPublished - Jan. 2023

Keywords

  • Anxiety
  • Bifidobacteria
  • Depression
  • Gut microbiota
  • Prenatal stress

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