Interspecies communication between Burkholderia cepacia and Pseudomonas aeruginosa

Shawn Lewenza, Michelle B. Visser, Pamela A. Sokol

Research output: Contribution to journalJournal Articlepeer-review

72 Citations (Scopus)

Abstract

Burkholderia cepacia and Pseudomonas aeruginosa are opportunistic pathogens that commonly cause pulmonary infections in cystic fibrosis patients and occasionally co-infect patients' lungs. Both organisms possess quorum-sensing systems dependent on N-acyl homoserine lactone (N-acyl-HSL). Cross-feeding assays demonstrated that P. aeruginosa and B. cepacia were able to utilize heterologous N-acyl-HSL signaling molecules. The ability of quorum-sensing genes from one species to complement the respective quorum-sensing mutations in the heterologous species was also examined. These studies suggest that B. cepacia CepR can use N-acyl-HSLs synthesized by RhlI and LasI and that P. aeruginosa LasR and RhlR can use N-acyl-HSLs synthesized by CepI. It is possible that a mixed bacterial population of B. cepacia and P. aeruginosa can coordinately regulate some of their virulence factors and influence the progression of lung disease due to infection with these organisms.

Original languageEnglish
Pages (from-to)707-716
Number of pages10
JournalCanadian Journal of Microbiology
Volume48
Issue number8
DOIs
Publication statusPublished - 2002

Keywords

  • Burkholderia cepacia
  • Cystic fibrosis
  • Pseudomonas aeruginosa
  • Quorum sensing

Fingerprint

Dive into the research topics of 'Interspecies communication between Burkholderia cepacia and Pseudomonas aeruginosa'. Together they form a unique fingerprint.

Cite this