Effect of Dietary β-Carotene on Hepatic Drug-Metabolizing Enzymes in Mice

Tapan K. Basu, Norman J. Temple, Joyce Ng

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26 Citations (Scopus)


The effects of dietary supplements of β-carotene (20-500 mg per kg diet) on hepatic microsomal drug-metabolizing enzyme activities were studied in mice. Supplementation for 14 days resulted in marked reductions in the concentrations of cytochrome P-450 and biphenyl 4-hydroxylase. The antipyrine N-demethylase and β-nitroanisol O-de-methylase activities, however, were unchanged. Also apparently unchanged were the hepatic concentrations of microsomal protein, lipid peroxides, and superoxide dismutase. Supplemental β-carotene was weakly protective against the acute toxic effects of an injection of 1,2-dimethylhydrazine (DMH), as indicated by a lowered mortality. This anti-carcinogenic action of β-carotene, including a protection against DMH-induced colon carcinogenesis, suggests an alteration by this carotenoid in the metabolism of carcinogens by the liver.

Original languageEnglish
Pages (from-to)95-102
Number of pages8
JournalJournal of Clinical Biochemistry and Nutrition
Issue number2
Publication statusPublished - 1987


  • 1,2-dimethylhydrazine toxicity
  • cytochrome P-450
  • demethylase
  • superoxide dismutase
  • β-carotene


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