TY - JOUR
T1 - Does selenium modify neurobehavioural impacts of developmental methylmercury exposure in mice?
AU - Folven, Kristin I.
AU - Glover, Chris N.
AU - Malde, Marian K.
AU - Lundebye, Anne Katrine
N1 - Funding Information:
The authors would like to thank Aase Heltveit and Berit Solli for technical expertise during mice experimentation and chemical analysis, respectively. Shalini Jayashankar is also thanked for the assistance on chemical analysis. The advice of Dr. Gillian Sales and Professor Christer Hogstrand at King's College London, and Professor Tore Syversen and Parvinder Kaur at the Norwegian University of Science and Technology is gratefully acknowledged. The study was funded by the Research Council of Norway, the EC FRP6 Integrated Project “Aquamax” (project no. 016249-2) and NIFES. The experiment was approved by the National Animal Research Authority, Norway.
PY - 2009/7
Y1 - 2009/7
N2 - There is controversy as to whether low-level chronic exposure to methylmercury (MeHg) through maternal fish consumption may cause subtle effects in the developing child, owing in part to the potential ameliorating effects of beneficial seafood nutrients. The aim of the present investigation was to assess the ameliorating potential of selenium (Se; as the naturally occurring methionine complex) on the neurobehavioural toxicity of foodborne MeHg (as the naturally occurring cysteinate) in prenatally exposed mice. Pups from dams exposed to a diet containing 3 mg/kg of MeHg fed throughout gestation showed delayed fur development and impaired performance in a motor function assessment. These effects were not apparent in pups born to dams concurrently exposed to Se (at 1.3 mg/kg). These results, using natural dietary forms of the elements administered through the relevant exposure pathway, suggest only minor impacts of MeHgCys on neurobehaviour, and possible amelioration of these effects by Se.
AB - There is controversy as to whether low-level chronic exposure to methylmercury (MeHg) through maternal fish consumption may cause subtle effects in the developing child, owing in part to the potential ameliorating effects of beneficial seafood nutrients. The aim of the present investigation was to assess the ameliorating potential of selenium (Se; as the naturally occurring methionine complex) on the neurobehavioural toxicity of foodborne MeHg (as the naturally occurring cysteinate) in prenatally exposed mice. Pups from dams exposed to a diet containing 3 mg/kg of MeHg fed throughout gestation showed delayed fur development and impaired performance in a motor function assessment. These effects were not apparent in pups born to dams concurrently exposed to Se (at 1.3 mg/kg). These results, using natural dietary forms of the elements administered through the relevant exposure pathway, suggest only minor impacts of MeHgCys on neurobehaviour, and possible amelioration of these effects by Se.
KW - Methylmercury
KW - Mice
KW - Neurobehavioural toxicity
KW - Prenatal exposure
KW - Selenium
UR - http://www.scopus.com/inward/record.url?scp=67349130182&partnerID=8YFLogxK
U2 - 10.1016/j.etap.2009.03.007
DO - 10.1016/j.etap.2009.03.007
M3 - Journal Article
AN - SCOPUS:67349130182
SN - 1382-6689
VL - 28
SP - 111
EP - 119
JO - Environmental Toxicology and Pharmacology
JF - Environmental Toxicology and Pharmacology
IS - 1
ER -