TY - JOUR
T1 - Current studies on the pathogenesis of melioidosis
AU - Woods, Donald E.
AU - Deshazer, David
AU - Moore, Richard A.
AU - Brett, Paul J.
AU - Burtnick, Mary N.
AU - Reckseidler, Shauna L.
AU - Senkiw, Michelle D.
N1 - Funding Information:
This work was supported by the Canadian Bacterial Diseases Network of Centres of Excellence Program. We gratefully acknowledge Marina Tom for outstanding technical assistance.
PY - 1999/2
Y1 - 1999/2
N2 - Burkholderia pseudomallei is a major cause of bacterial septicemias in many parts of the world, particularly Thailand; the known geographic range of the organism appears to be enlarging as awareness of the organism and the disease it causes - melioidosis - increases. B. pseudomallei is intrinsically resistant to most antibiotics, and our knowledge of B. pseudomallei pathogenesis is lacking. Thus, the long-term objective of our research is to define at a molecular level the pathogenesis by combining genetic, immunologic, and biochemical approaches with animal model studies. Basic studies on B. pseudomallei pathogenesis are acutely needed to provide a knowledge base to rationally design new modes of therapy directed against this organism.
AB - Burkholderia pseudomallei is a major cause of bacterial septicemias in many parts of the world, particularly Thailand; the known geographic range of the organism appears to be enlarging as awareness of the organism and the disease it causes - melioidosis - increases. B. pseudomallei is intrinsically resistant to most antibiotics, and our knowledge of B. pseudomallei pathogenesis is lacking. Thus, the long-term objective of our research is to define at a molecular level the pathogenesis by combining genetic, immunologic, and biochemical approaches with animal model studies. Basic studies on B. pseudomallei pathogenesis are acutely needed to provide a knowledge base to rationally design new modes of therapy directed against this organism.
KW - Burkholderia pseudomallei
KW - Melioidosis
KW - Molecular biology
KW - Pathogenesis
UR - http://www.scopus.com/inward/record.url?scp=0032735562&partnerID=8YFLogxK
U2 - 10.1016/S1286-4579(99)80007-0
DO - 10.1016/S1286-4579(99)80007-0
M3 - Review article
C2 - 10594980
AN - SCOPUS:0032735562
SN - 1286-4579
VL - 1
SP - 157
EP - 162
JO - Microbes and Infection
JF - Microbes and Infection
IS - 2
ER -