Current studies on the pathogenesis of melioidosis

Donald E. Woods, David Deshazer, Richard A. Moore, Paul J. Brett, Mary N. Burtnick, Shauna L. Reckseidler, Michelle D. Senkiw

    Research output: Contribution to journalReview articlepeer-review

    53 Citations (Scopus)


    Burkholderia pseudomallei is a major cause of bacterial septicemias in many parts of the world, particularly Thailand; the known geographic range of the organism appears to be enlarging as awareness of the organism and the disease it causes - melioidosis - increases. B. pseudomallei is intrinsically resistant to most antibiotics, and our knowledge of B. pseudomallei pathogenesis is lacking. Thus, the long-term objective of our research is to define at a molecular level the pathogenesis by combining genetic, immunologic, and biochemical approaches with animal model studies. Basic studies on B. pseudomallei pathogenesis are acutely needed to provide a knowledge base to rationally design new modes of therapy directed against this organism.

    Original languageEnglish
    Pages (from-to)157-162
    Number of pages6
    JournalMicrobes and Infection
    Issue number2
    Publication statusPublished - Feb. 1999


    • Burkholderia pseudomallei
    • Melioidosis
    • Molecular biology
    • Pathogenesis


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