TY - JOUR
T1 - Cabbage and vitamin E
T2 - Their effect on colon tumor formation in mice
AU - Temple, Norman J.
AU - El-Khatib, Shukri M.
N1 - Funding Information:
The authors thank Mrs. Myrna Nieves for skillful technical assistance, Mrs. Mabel Baaske, Mrs. Sandra Casovan and Mr. Arthur Stansfield for histological work and Dr. Lawrence Jewel1 (Department of Pathology, University Hospital, Edmonton) for advice on the interpretation of colon tumors. We also thank The Alberta Heritage Foundation for Medical Research for financial support.
PY - 1987/4
Y1 - 1987/4
N2 - The effects of cabbage and vitamin E on colon carcinogenesis were investigated in Swiss mice treated with 1,2-dimethylhydrazine. Throughout the experiment the mice were fed a laboratory chow diet (46 mg vitamin E per kg) or chow containing 13 g cabbage per 100 g or 180 mg vitamin E per kg. Starting after 31 days of diet treatment the mice received 7 weekly s.c. injections of DMH. They were sacrificed 17 weeks after the first dose of DMH. While diet did not significantly alter colon tumor response, some trends were observed. Female mice given cabbage had a higher incidence (percent of mice with a tumor) and multiplicity (tumors per tumor bearing mouse) of colon tumors. Males were little affected by cabbage apart from a lower incidence of adenocarcinomas. Compared with mice fed the control diet those given vitamin E had a higher colon tumor incidence. This effect, which was stronger in females, was due to an increased incidence of adenomas. Vitamin E had little apparent affect on tumor multiplicity apart from a reduction in adenocarcinomas in females and adenomas in males. The data do not support the view that cabbage and vitamin E are protective against colon cancer.
AB - The effects of cabbage and vitamin E on colon carcinogenesis were investigated in Swiss mice treated with 1,2-dimethylhydrazine. Throughout the experiment the mice were fed a laboratory chow diet (46 mg vitamin E per kg) or chow containing 13 g cabbage per 100 g or 180 mg vitamin E per kg. Starting after 31 days of diet treatment the mice received 7 weekly s.c. injections of DMH. They were sacrificed 17 weeks after the first dose of DMH. While diet did not significantly alter colon tumor response, some trends were observed. Female mice given cabbage had a higher incidence (percent of mice with a tumor) and multiplicity (tumors per tumor bearing mouse) of colon tumors. Males were little affected by cabbage apart from a lower incidence of adenocarcinomas. Compared with mice fed the control diet those given vitamin E had a higher colon tumor incidence. This effect, which was stronger in females, was due to an increased incidence of adenomas. Vitamin E had little apparent affect on tumor multiplicity apart from a reduction in adenocarcinomas in females and adenomas in males. The data do not support the view that cabbage and vitamin E are protective against colon cancer.
UR - http://www.scopus.com/inward/record.url?scp=0023101014&partnerID=8YFLogxK
U2 - 10.1016/0304-3835(87)90058-9
DO - 10.1016/0304-3835(87)90058-9
M3 - Journal Article
C2 - 3567889
AN - SCOPUS:0023101014
SN - 0304-3835
VL - 35
SP - 71
EP - 77
JO - Cancer Letters
JF - Cancer Letters
IS - 1
ER -
